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P21 (10mg)
$155.00
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P21 is a synthetic tetrapeptide derived from the biologically active region of ciliary neurotrophic factor. It is studied for its potential role in supporting neurotrophic signalling, cognitive function, and neuronal resilience. In research settings, P21 is investigated for its influence on synaptic plasticity, neurogenesis, and mechanisms associated with memory, learning, and brain aging.
Generic Name:
P21
Compound Information:
Molecular Weight: 578.3 g/mol
Formula: C₃₀H₅₄N₆O₅
Anabolic Rating: N/A
Androgenic Rating: N/A
Dosage (Male)
100-500 mcg once daily
Dosage (Female)
100-500 mcg once daily
Dosage Frequency
Once daily
Dosage Type
Subcutaneous Injection
Active Half-Life
N/A
Chemical Name
AC–DGGL(A)G-NH2
Stack With...
BPC-157, TB-500, Semax, and Selank
Post-Cycle Therapy
N/A
Neurotrophic Signaling and Cognitive Support
P21 is a tetrapeptide derived from the most active region of ciliary neurotrophic factor that is studied for its potential to support neurotrophic signalling and cognitive function. Research highlights its role in promoting neuronal survival, neurogenesis, and synaptic plasticity, making it relevant in studies targeting memory, learning, and brain resilience.
Neurodegenerative Disease Research
P21 is closely associated with research into neurodegenerative conditions such as Alzheimer’s disease. Studies report its ability to reduce Tau protein build-up and influence amyloid plaque production in preclinical models, positioning it as a promising peptide for neuroprotective investigation.
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Brain-Derived Neurotrophic Factor Modulation
Beyond general cognitive support, P21 is studied for its potential to increase levels of brain-derived neurotrophic factor (BDNF), which supports neurogenesis and neural network integrity. This makes it relevant in research focused on sustained cognitive performance and cellular neural health.
Cross-Blood-Brain-Barrier Neuropeptide
P21’s small molecular size and design allow it to cross the blood-brain barrier more effectively than larger neurotrophic proteins, making it valuable in research models that require direct central nervous system engagement. This property supports its use in studies examining brain health, neural repair, and cognitive adaptability.
Need Help with the Correct Peptide Mixture?
Our peptide mixing calculator takes the guesswork out of dosing, giving you an exact, easy-to-follow guide based on your vial, syringe, and target dosage. Whether you’re new to peptides or simply want to double-check your math, we’ve made it simple and straightforward.
Just enter your total syringe volume, the amount of peptide in your vial, how much water you’re adding, and your desired peptide dose. The calculator will do the rest — making sure you get accurate measurements for safe, consistent use every time.
For A MCG Dose, Draw Up To Tick Mark .
These ranges are general, research-use suggestions to help you prepare your peptides. This calculator and recommended doses are not medical advice. Start low, assess tolerance, and adjust cautiously.
Dosage (Male)
100-500 mcg once daily
Dosage (Female)
100-500 mcg once daily
Dosage Frequency
Once daily
Dosage Type
Subcutaneous Injection
Our Guide to Intramuscular Injection
Gather Your Equipment
Before you begin your injection, make sure all your supplies are organized and within reach. You’ll need the injectable compound, a clean single-use syringe and needle, alcohol pads, a proper sharps disposal container, cotton balls or gauze for cleanup, and optionally, a mirror if you’re injecting yourself. Having everything set up in advance helps the process go smoothly without unnecessary interruptions. Prioritizing preparation and safety supports proper technique and long-term well-being.
Compound Extraction
After gathering all the required items, it’s time to draw the medication from the vial. Hold the vial upright and gently pull back on the plunger to fill the syringe with the exact amount prescribed. Make sure to follow your healthcare provider’s directions precisely. Once filled, tap the syringe lightly to bring any air bubbles to the top. Then, carefully press the plunger to expel the air, stopping when only the prescribed amount remains. Review the recommended injection depth before continuing.
Preparation Before Injection
To begin, select a clean, bright space where you can work comfortably. Wash your hands thoroughly with soap and water to prevent contamination. Then, prepare the injection site—this may be your thigh, glute, or upper arm, depending on your provider’s guidance. No matter the location, clean the area using an alcohol swab to eliminate oils, debris, or bacteria. Let the area air dry fully before proceeding to the injection.
Compound Administration
With the syringe ready, you can now give the injection. Grip the syringe securely and insert the needle into the chosen site at the correct depth. Gently pull back on the plunger—if blood enters the syringe, remove it and start again with a new needle. If no blood appears, push the plunger slowly and steadily to deliver the medication. A gradual injection helps maintain comfort and control. Once the dose is fully delivered, remove the needle carefully and dispose of it safely.
Incorporate P21 Into a Stack
P21 is often researched alongside peptides such as BPC-157, TB-500, Semax, and Selank in multi-pathway protocols focused on neural resilience and whole-system recovery. In these research contexts, P21 serves as the neurotrophic and cognitive support component, while complementary peptides may address peripheral tissue repair, stress response, or neurotransmitter regulation.
Usage Guidelines For P21
P21 is typically administered via subcutaneous injection in protocols focused on cognitive support, neuroprotection, and neuronal repair research. Common dosing regimens involve daily administration or five consecutive days per week using low microgram doses, reflecting P21’s activity at relatively small concentrations. Protocols are often organized into defined cycles to support neurological adaptation and sustained neurotrophic signalling.
Timing of administration is flexible and is not dependent on fasting, physical activity, or circadian rhythm, as P21 does not directly influence metabolic or performance pathways. Maintaining consistent daily timing throughout a protocol may help support stable cognitive and cellular responses.
After reconstitution with bacteriostatic water, P21 should be stored at 2°C to 8°C (36°F to 46°F) and protected from light to preserve peptide stability throughout the dosing period.
Consult With a Healthcare Provider
Before considering the use of peptides, it’s important to speak with a licensed medical professional. They can assess your overall health, explain the potential benefits and risks, and provide tailored advice that fits your personal goals and medical history.
Choose Reputable, Quality Sources
To minimize the risk of contaminated or fake products, always source peptides from reputable vendors like Pacific Peptides. Stick to well-known suppliers who follow strict quality protocols and have earned a solid track record within the fitness or medical community.
Begin
Conservatively
When starting peptides, begin with the lowest dose that may offer results. Increase gradually only if necessary, paying close attention to how your body responds and watching for any unwanted effects along the way.
PRIORITISE RECOVERY & MONITORING
Peptide protocols should be supported by proper recovery and regular self monitoring. Prioritizing sleep, nutrition, hydration, and stress management helps maximize results while reducing the risk of unwanted effects. Allowing adequate time between cycles supports long term metabolic health and overall well being.
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