Retatrutide isn’t just for weight loss — early studies show it may also lower blood pressure, and in some cases, it works better than semaglutide (Ozempic/Wegovy) or tirzepatide (Mounjaro/Zepbound).

Retatrutide: More Than Just a Weight Loss Drug

Most headlines about retatrutide focus on its jaw-dropping weight loss numbers — some participants in clinical trials lost up to 24% of their body weight. That’s like turning a 250-pound person into 190 pounds without surgery.

But here’s something most people don’t realize: retatrutide also lowers blood pressure, and it does so in a way that doctors are paying close attention to.

If you’ve been wondering “does retatrutide lower blood pressure?” the simple answer is yes — and the effect looks strong enough to matter for long-term heart health.

How Much Does Retatrutide Lower Blood Pressure?

Let’s put some numbers on it.

• A 2025 research review found that people taking retatrutide saw their systolic blood pressure (the top number) drop by around 7 points compared to those on a placebo.
  
• That’s more than tirzepatide (about –5 points) and semaglutide (about –3 points).
  
• The bottom number (diastolic blood pressure) also dipped by 1–2 points, which may not sound big, but it was still a reliable, statistically proven change.
  
  

Why does this matter? Even a small drop makes a difference. Studies show that lowering systolic blood pressure by just 5 points can cut the risk of strokes and heart attacks by around 10%. So a 7-point reduction could be a real game-changer, especially for people already at risk of heart problems.

And the effect isn’t just a fluke of one trial. In multiple Phase 2 studies, people taking higher doses of retatrutide (8–12 mg) consistently saw their blood pressure improve.

Think of it this way: losing weight is great for your heart, but lowering blood pressure at the same time is like doubling the safety net.

Why Does Retatrutide Lower Blood Pressure?

Doctors believe there are two big reasons why this drug helps with blood pressure.

1. Weight loss itself
   Carrying extra weight puts pressure on the heart and blood vessels. Drop 20–25% of your body weight, and naturally, your heart doesn’t have to work as hard.
   
   
2. Direct effects on the body
   Weight loss only explains part of the story. Early research suggests retatrutide may directly affect how blood vessels relax, how the kidneys handle salt and water, and how the body regulates fluid balance. That means its blood pressure benefits go beyond the scale.
   

This “double effect” — both indirect and direct — is what makes scientists so excited about retatrutide’s potential.

Retatrutide vs. Semaglutide vs. Tirzepatide: Who Wins the Blood Pressure Battle?

All three drugs — semaglutide, tirzepatide, and retatrutide — were first designed for weight management and diabetes. But their impact on blood pressure is becoming part of the bigger story.

Here’s a simple breakdown:

• Retatrutide: ~–7 mmHg systolic (currently the strongest effect reported).
  
• Tirzepatide: ~–5 mmHg systolic.
  
• Semaglutide: ~–3 mmHg systolic.
  

That may not seem like a wide gap, but in cardiology, those few points can translate into thousands of lives saved when applied across millions of patients. If these numbers hold up in larger studies, retatrutide could set a new standard for not just weight management but also heart protection.

What This Means for Everyday People

So what does a 7-point blood pressure drop really mean if you’re sitting at home reading this?

• If your blood pressure is 140/90, retatrutide could, on average, bring it closer to 133/88. That’s enough to shift someone from the “high blood pressure” range into a safer zone.
  
• For people who are already taking blood pressure medication, the combo of weight loss + drug therapy might push numbers down even further. That’s good news, but it also means doctors may need to adjust doses to avoid blood pressure dropping too low.
  
• If you’re only a little above normal, the benefit might be smaller, but paired with weight loss, it could still mean avoiding medication altogether in the future.
  

In short: retatrutide may not replace blood pressure drugs, but it could make them work better or reduce the need for them. Phase 2 trials proved to show very positive results, with multiple dosages tested upon.

The Bottom Line

Retatrutide is shaping up to be a triple-threat drug: helping with weight loss, blood pressure control, and potentially heart health.

• It lowers systolic blood pressure by about 7 points on average.
  
• That makes it more effective than semaglutide and tirzepatide in this area.
  
• Could help Canadians just like you not only slim down, but also reduce the risk of serious cardiovascular events.
  

In sum, as time continues to pass If you’re interested in learning more about this topic, and/or researching our products, please feel free to reach out to our customer support team.